摘要
Rh/ZhaoPhos-catalyzed asymmetric hydroge nation of a series of(E)-2-(chro man-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities(up to 99%yield,98%ee).Moreover,the gram-scale hydrogenation could be performed well in the presence of 0.02 mol%catalyst loading(TON=5000),the hydrogenation product was easily converted to access other important compounds,which demonstrated the synthetic utility of this asymmetric catalytic methodology.
基金
the National Natural Science Foundation of China(Nos.21432007,21502145,21602172)
Wuhan Morning Light Plan of Youth Science and Technology(No.2017050304010307)
the Fundamental Research Funds for and the Central Universities(No.2042018kf0202)
Shenzhen Nobel Prize Scientists Laboratory Project(No.C17783101)
Science and Technology Innovation Committee of Shenzhen(No.KQTD 20150717103157174)
SZDRC Discipline Construction Program
The Program of Introducing Talents of Discipline to Universities of China(111 Project)。
