牙龈卟啉单胞菌菌毛与消化道肿瘤关系研究

Study on the Relationship between Porphyromonas gingivalis Fimbriae and Digestive Tract Tumors

牙龈卟啉单胞菌(Pg)是引起牙周病的一个重要致病因素,并可引起多种疾病,如冠心病、糖尿病、肿瘤等。Pg与消化道肿瘤,包括口腔鳞状细胞癌、食管鳞癌、胰腺癌以及结直肠癌有密切关系。本文重点介绍Pg菌毛的致病及免疫颠覆机制、Pg与消化道肿瘤的关系。

Porphyromonas gingivalis is an important pathogenic factor that causes periodontal disease, and can cause many diseases such as coronary heart disease, diabetes, tumors and so on. Porphyromonas gingivalis is closely related to tumors of the digestive tract, including oral squamous cell carcinoma, esophageal squamous cell carcinoma, pancreatic cancer and colorectal cancer. This article focuses on the pathogenicity and immune damage mechanism of Porphyromonas gingivalis fimbriae, and the relationship between Porphyromonas gingivalis and digestive tract tumors.