食管鳞癌根治性同步放化疗

Radical Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

对于拒绝手术切除或不可切除的局部进展期食管鳞状细胞癌患者,相比于单纯放疗,同步放化疗已被临床验证可显著延长生存期,故被认为是标准治疗策略,但在临床应用中仍存在着一些问题,如致命性的放射性肺炎等。因此,合理的化疗方案和放疗计划的实施,是保证根治性同步放化疗疗效的关键所在。

For patients with locally advanced esophageal squamous cell carcinoma who refuse surgical resection or are unresectable, concurrent chemoradiotherapy has been clinically shown to significantly prolong survival compared with radiotherapy alone, so it is considered as the standard treatment strategy. But there are some problems about chemoradiotherapy for esophageal squamous cell carcinoma such as the fatal radiation pneumonitis. Therefore, the implementation of reasonable chemotherapy plan and radiotherapy plan is the key to ensure the curative effect of radical synchronous radiotherapy and chemotherapy.