食管癌预后的生物标志物研究进展

Recent Advances of Biomarkers in Prognosis of Esophageal Cancer

食管癌是全球最常见的消化道恶性肿瘤之一,其发生发展机制复杂多样,发现时常已至中晚期,甚至转移,故死亡率高、预后差。传统方法多采用影像学及内镜活检对其进行临床分期评估,在一定程度上取决于医师的主观判断与经验,存在不足。随着科学技术的发展,有关食管癌的生物预后标记物逐渐得到重视。结合传统方式,综合对患者预后进行评价,在提高生存率及生存质量等方面具有重要意义。本文针对食管癌预后指标的最新研究进行综述,为临床医生进行治疗及预后判断提供更加多样且客观的方法。

Esophageal cancer is one of the most common gastrointestinal malignancies in the world. Its occurrence and development mechanism is complex and diverse. It is often found to be in the middle or late stage,or even metastasized,so its mortality rate is high and the prognosis is poor. Imaging and endoscopic biopsy were traditional methods mostly used to evaluate the clinical staging, which mostly depends on the subjective judgment and experience of the doctors. With the development of science and technology, the biological prognostic markers of esophageal cancer have been paid more and more attention. It is of great significance to comprehensively evaluate the prognosis of patients in combination with traditional methods in improving the survival rate and quality of life. This paper reviews the latest studies on prognostic indicators of esophageal cancer, in order to provide clinicians with more diversified and objective ways for treatment and prognosis judgment.