鼻咽癌患者91例放化疗后应用中药维持治疗的安全性报告

Safety report of 91 cases with nasopharyngeal carcinoma treated with traditional Chinese medicine after radiotherapy and chemotherapy

目的:通过观察91例鼻咽癌患者中药维持治疗的不良反应,探讨中药复方在恶性肿瘤维持治疗中的安全性。方法:收集放化疗结束后鼻咽癌患者91例,辨证予中药复方水煎剂维持治疗至少3个月,记录用药期间临床症状以及用药前后血常规、肝肾功能及心电图。结果:1例(1.1%)出现Ⅱ度腹泻;2例(2.2%)出现Ⅰ度白细胞下降,2例(2.2%)出现Ⅰ度贫血,1例(1.1%)出现Ⅰ度转氨酶升高,未见心电图异常者。结论:鼻咽癌患者放化疗后合理使用中药复方水煎剂维持治疗,未观察到明显不良反应,安全性较高,"有故无殒"理论在评价恶性肿瘤中药治疗安全性方面有指导意义。

Objective:By observing the adverse reactions of Chinese medicine maintenance treatment in 91 patients with nasopharyngeal carcinoma,the safety of Chinese medicine compound in the maintenance treatment of malignant tumors was discussed.Methods:A total of 91 patients with nasopharyngeal carcinoma after radiotherapy and chemotherapy were collected,with Chinese medicine decoction for maintenance treatment for at least 3 months based on syndrome differentiation.Then,record patients’clinical symptoms during medication,blood routine,liver and kidney function and electrocardiogram before and after medication.Results:1 patient(1.1%)had gradeⅡdiarrhea;2 patients(2.2%)had gradeⅠleukopenia,2 patients(2.2%)had gradeⅠanemia,1 patient(1.1%)had gradeⅠtransaminase elevation,no patient had appeared abnormal in ECG.Conclusion:Patients with nasopharyngeal carcinoma are reasonably treated with traditional Chinese medicine decoction after radiotherapy and chemotherapy,no obvious adverse reactions are observed,and safety is high.The‘medicine leads to no damage in sick condition’theory has guiding significance in evaluating the safety of traditional Chinese medicine treatment of malignant tumors.