急性脑出血患者凝血功能指标对血肿扩大的预测价值分析

Value of coagulation function indicators in prediction of hematoma enlargement in patients with acute cerebral hemorrhage

目的探讨急性脑出血患者凝血功能指标对血肿扩大的预测价值。方法选取2017年10月至2019年1月就诊于该院的急性脑出血患者95例为研究对象。入院后进行凝血功能指标检测,根据CT检查中血肿体积变化将患者分为血肿扩大组(n=20)和血肿未扩大组(n=75)。结果血肿扩大组凝血酶时间(TT)、凝血因子Ⅱ水平均高于血肿未扩大组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,凝血因子Ⅱ活性升高是急性脑出血患者发生血肿扩大的危险因素(OR=1.101,95%CI:1.012~1.199)。结论脑出血患者预后评估中,凝血功能指标的检测可反映患者血肿扩大情况,凝血因子Ⅱ活性升高使急性脑出血患者出现血肿扩大的风险增加。

Objective To discuss the value of coagulation function indicators in prediction of hematoma enlargement in patients with acute cerebral hemorrhage.Methods A total of 95 patients with acute cerebral hemorrhage from October 2017 to January 2019 were selected as research subjects who had perform coagulation function tests.According to the change of hematoma volume displayed on CT,the hematoma enlargement group(n=20)and the non-hematoma enlargement group(n=75)were set.Results Thrombin time(TT)and coagulation factorⅡin the hematoma enlargement group were significantly higher than that of non-hematoma enlargement group(P<0.05).Multivariate Logistic regression showed that elevated coagulation factorⅡactivity was the risk factors of hematoma enlargement(OR=1.101,95%CI:1.012-1.199).Conclusion In the assessment of the prognosis of patients with cerebral hemorrhage,the coagulation function indicators test can reflect the enlargement of the patient′s hematoma.Elevated coagulation factorⅡactivity may increase the risk of hematoma enlargement in patients with acute cerebral hemorrhage.