乳酸杆菌在预防尿路感染复发中的研究进展

The preventing roles of Lactobacillus in recurrence of urinary tract infection

尿路感染是最常见的感染性疾病之一,在部分人群中的高复发率为其显著特点。预防尿路感染的反复发作是减少抗菌药物使用以及降低患者经济负担的重要措施。乳酸杆菌作为一种重要的益生菌,在体外试验及动物模型中看到对尿路感染病原体的抑制作用及对动物感染模型的保护作用,一些临床研究也提示乳酸杆菌可能对预防尿路感染复发存在有益作用,因此可能成为非抗菌药物预防的选择。为帮助临床对这一领域研究的认识,本文就乳酸杆菌在体外、动物以及临床研究中的进展进行综述。

Urinary tract infection is one of the most common infectious diseases, and its high recurrence rate in some populations is a significant feature. Preventing recurrent episodes of urinary tract infection is an important measure to reduce antibiotic use and reduce the financial burden on patients. Lactobacillus, as an important probiotic, has been found inhibitory effects on uropathogenic pathogens and protective effects on animal infection models. Some clinical studies have also suggested that Lactobacillus may prevent urinary tract infections from recurring and therefore may be a non-antibiotic prevention option. To help clinician understanding this field of research, this article reviews the roles of Lactobacillus in the research of laboratory, animal model and patients.