通过一步法构建顺式-β,γ-二取代γ-丁内酯合成(+)-Phaseolinic Acid

Synthesis of(+)-Phaseolinic Acid via One-Step Construction of cis-β,γ-Disubstitutedγ-Butyrolactone

通过线性合成方法五步合成了(+)-Phaseolinic Acid,其中包含对映选择性地1,6-硼化和一步合成顺式-β,γ-二取代γ-丁内酯两个关键步骤。所有起始原料均廉价且易获得,避免了过多的合成前或合成后操作。

(+)-Phaseolinic acid was synthesized through a linear five-steps synthetic route,in which enantioselective 1,6-borylation and one-step synthesis of cis-β,γ-disubstitutedγ-butyrolactone are two key steps.All starting materials are commercially available and cheap so as to avoid excessive pre-or post-synthetic manipulations.