纯亲水自组装体构建抗菌纳米材料

Fabrication of Antibacterial Nanomaterials via Pure Hydrophilic Self⁃assembly

以纯亲水无规共聚物poly(DMAEMA-co-AA)在纯水相中诱导自组装,构建出可用于负载抗菌活性成分的纳米自组装体。结果表明,当AA链段质量分数为51.6%时poly(DMAEMA-co-AA)在水中更倾向于形成球状与多孔球状自组装体;另外,随着pH值的升高,自组装体表现出“呼吸”作用,从小尺寸的球状逐步膨胀为多孔球状自组装体,可稳定负载85%以上抗菌成分(对羟基苯甲酸乙酯钠)构建抗菌纳米材料,得到对数抗菌值高于4.4的抗菌材料,用于抗菌包装后常温食品存储的时间显著延长。

The self-assembly was induced for a hydrophilic random copolymer of poly(DMAEMA-co-AA)in pure water,and the self-assemblies were fabricated by loading antibacterial active components.The results indicated that when the random copolymer contained 51.6 wt% of AA,poly(DMAEMA-co-AA)tended to form spherical and porous spherical self-assemblies in pure water.With an increase of pH value,the self-assemblies exhibited a“breathing”behavior and varied from small-size spheres to porous spheres.More than 85%ethyl p-hydroxybenzoate sodium as an antibacterial component could be stably loaded on the self-assemblies to form the antibacterial nanomaterials.Moreover,the other antibacterial components could also be loaded on the self-assemblies.The antibacterial nanomaterials achieved a logarithmic antibacterial value of above 4.4,and they could prolong the storage time of food at room temperature when used for anti-bacterial packaging.