核酸感受器与肿瘤的关系

Relationship between Nucleic Acid Sensing Pattern Recognition Receptors and Tumor

先天免疫系统提供了抵御病原体感染的第一道防线。它依赖于一种感受器—模式识别受体(pattern recognition receptors,PRRs),可检测病原体相关分子模式和损伤相关分子模式信号。核酸感受器是PRRs主要亚型之一,通过识别胞内或胞外的核酸导致多种促炎症细胞因子的产生,从而诱导免疫反应以保护被病原体感染的寄主。研究表明,这些核酸感受器也参与肿瘤的发展。该文就各种核酸感受器与肿瘤的关系进行了综述。

The innate immune system is one of the first and most important lines of defense against pathogen.It depends on a kind of receptors called PRRs (pattern recognition receptors),which recognizes pathogen-associated molecular patterns or damage-associated molecular patterns.Nucleic acid sensing pattern-recognition receptors are one of the major subsets of PRRs,which can induce the production of pro-inflammatory cytokine to trigger immunity activation by perceiving extracellular or intracellular nucleic acid,thereby protecting the host from being infected by the pathogen.Recent researches show that nucleic acid sensing pattern recognition receptors participate in progress and occurrence of tumor.This review focuses on the current knowledge about the relationship between nucleic acid sensing pattern recognition receptors and tumor.