补气活血方对下肢动脉硬化闭塞症患者血清hs-CRP、UA、UAT的影响

Effect of Buqihuoxue Recipe on Serum Hs CRP,UA and UAT in Patients with Arteriosclerosis Obliterans of Lower Extremities

目的:探究补气活血方对下肢动脉硬化闭塞症(ASO)患者血清超敏C反应蛋白(hs-CRP)、尿酸(UA)、尿酸盐转运蛋白(UAT)的影响。方法:选择ASO患者72例,常规ASO控制及西药治疗患者作为对照组36例,控制疗法联合补气活血方治疗患者作为观察组36例,收集短期疗效指标(治疗1个月后hs-CRP、UA、UAT水平及临床疗效率)、1年随访结果。结果:经治疗后,2组患者下肢动脉及其分支清晰、无闭塞发生,血清中hs-CRP、UA、UAT水平优于治疗前,且观察组hs-CRP、UA、UAT水平优于对照组差异有统计学意义;观察组症状改善度高于对照组差异有统计学意义;1年随访结束后,观察组有效率显著升高,有效组和无效组hs-CRP、UA、UAT水平比较差异有统计学意义,且各指标与ASO临床症状呈相关关系,证实hs-CRP、UA、UAT联合检测对疾病转归预测价值高于单独检测。结论:hs-CRP、UA、UAT与ASO的发生发展密切相关,补气活血方可改善hs-CRP、UA、UAT水平提高临床疗效,在治疗中关注血清hs-CRP、UA、UAT的可定量对临床效果及预后具有重要意义。

Objective:To explore the effects of Buqi Huoxue Recipe on serum high sensitive C-reactive protein(hs CRP),uric acid(UA)and urate transporter(UAT)in patients with arteriosclerosis obliterans(ASO).Methods:From March 2017 to September 2018,72 patients with ASO who were diagnosed and treated in the geriatric department of our hospital were selected.The patients with conventional ASO control and Western medicine treatment were selected as the control group(n=36).The patients with control therapy combined with Invigorating Qi and activating blood formula were selected as the observation group(n=36).The short-term efficacy indexes(hs CRP,UA,UAT level and clinical treatment efficiency after one month of treatment)and the follow-up results of one year were collected.Results:After treatment,the arteries and branches of the lower extremities were clear and no occlusion occurred in the two groups.The level of hs-CRP,UA,UAT in serum was better than that before treatment,and the level of hs-CRP,UA,UAT in observation group was better than that in control group,the difference was statistically significant.After one-year follow-up,the effective rate of the observation group increased significantly,there were significant differences in the levels of hs CRP,UA and UAT between the ineffective group and the effective group,and each index was correlated with the clinical symptoms of ASO;the combined detection of hs CRP,UA and UAT had a higher predictive value for the prognosis of disease than the single detection.Conclusion:The occurrence and development of ASO are closely related to hs CRP,UA and UAT.Invigorating Qi and promoting blood circulation can improve the level of hs CRP,UA and UAT and improve the clinical effect.It is of great significance to pay attention to the quantification of serum hs-CRP,UA,UAT in the treatment of clinical effect and prognosis.