BTBD7和E-cadherin在126例宫颈鳞状细胞癌中的表达及意义

Expression of BTBD7 and E-Cadherin in 126 Cases with Cervical Squamous Cell Carcinoma and Its Significance

[目的]探讨BTB/POZ结构域蛋白7(BTB/POZ domain containing protein 7,BTBD7)和E-钙黏附蛋白(epithelia cadherin,E-cadherin)在宫颈鳞状细胞癌中的表达及意义。[方法]用免疫组化SP法检测126例宫颈鳞状细胞癌和42例正常宫颈组织中BTBD7和E-cadherin的表达,并分析宫颈鳞状细胞癌组织中的表达及与临床病理特征和预后的关系。[结果] BTBD7和Ecadherin在126例宫颈鳞状细胞癌组织中的阳性率分别为70.6%(89/126)和27.8%(35/126),在正常组织中的阳性表达率分别为16.7%(7/42)和100.0%(42/42),差异均有统计学意义(P<0.001)。BTBD7、E-cadherin在宫颈鳞状细胞癌组织中的表达与肿瘤的局部浸润、分化程度、FIGO分期和淋巴结转移显著性相关(P<0.05)。宫颈鳞状细胞癌组织中BTBD7和E-cadherin表达呈负相关(r=-0.223,χ2=6.245,P=0.012)。多因素Cox回归分析显示FIGO分期、淋巴结转移和BTBD7表达水平是宫颈鳞状细胞癌预后的独立因素(P<0.05)。[结论] BTBD7在宫颈鳞状细胞癌的进展中起一定作用,同时对于预测宫颈癌的预后具有一定的意义。

[Objective] To investigate the expression and significance of BTB/POZ domain containing protein 7(BTBD7) and E-cadherin in cervical squamous cell carcinoma. [Methods] The expression of BTBD7 and E-cadherin was detected with immunohistochemical SP method in 126 samples of cervical squamous cell carcinoma and 42 samples of normal cervical tissues. The relationship of the expression of BTBD7 and E-cadherin with clinicopathological features of cervical squamous cell carcinoma was analyzed with multivariate Cox regression. [Results] The positive rates of BTBD7 and E-cadherin in 126 cases of cervical squamous cell carcinoma were 70.6%(89/126) and 27.8%(35/126),respectively,and the positive expression rates in normal cervical tissues were 16.7%(7/42)and 100.0%(42/42)(P <0.05). The expression of BTBD7 and E-cadherin in cervical squamous cell carcinoma was significantly correlated with local invasion,differentiation,FIGO stage and lymph node metastasis(P<0.05). There was a negative correlation between BTBD7 and E-cadherin expression in cervical squamous cell carcinoma(r=-0.223,χ2=6.245,P=0.012). Multivariate Cox regression analysis showed that the FIGO stage,lymph node metastasis and BTBD7 expression were independent prognostic factors of cervical squamous cell carcinoma(P<0.05). [Conclusion] BTBD7 may be involved in the progression of cervical squamous cell carcinoma and has a certain significance for predicting the prognosis of cervical cancer.