COPD患者相关炎性因子水平与其病情严重程度的相关性研究

Relationship between related inflammatory factors levels and severity of disease in patients with COPD

探讨慢性阻塞性肺病(COPD)患者的可溶性髓系细胞触发受体-1(sTREM-1)、结缔组织生长因子(CTGF)、亲环素-A(CyPA)水平与其病情严重程度的相关性。ELISA检测COPD患者与健康人血清sTREM-1、CTGF、CyPA水平。结果显示,COPD患者sTREM-1、CTGF、CyPA水平高于健康人。随着肺功能分级的增加,COPD患者血清中sTREM-1、CTGF、CyPA水平也随之增加。sTREM-1、CTGF、CyPA水平与FEV1/FVC呈现显著负相关性(P<0.05)。Logistic回归分析显示,sTREM-1、CTGF、CyPA水平是严重COPD的影响因素。结果说明,COPD患者血清sTREM-1、CTGF、CyPA水平显著升高,并且与患者肺功能指标显著相关,可用于判断COPD患者的病情严重程度。

To explore the relationship between the levels of soluble myeloid cell trigger receptor-1(sTREM-1), connective tissue growth factor(CTGF), cyclophilin-A(CyPA) and the severity of chronic obstructive pulmonary disease(COPD). The levels of sTREM-1, CTGF and CyPA between COPD patients and healthy people were detected by ELISA. The results showed that the levels of sTREM-1, CTGF and CyPA in the COPD patients were higher than those in the health. With the increase of lung function grade, serum levels of sTREM-1, CTGF and CyPA in COPD patients also increased. There was a significant negative correlation between sTREM-1, CTGF, CyPA and FEV1/FVC(P<0.05). Logistic regression analysis showed that the levels of sTREM-1, CTGF and CyPA were the influencing factors of severe COPD. The study indicated that serum levels of sTREM-1, CTGF and CyPA were significantly increased in COPD patients, and they were significantly correlated with pulmonary function indexes, which can be used to judge the severity of COPD patients.