CTC检测在预测肺癌复发转移及患者预后中的意义

Implication of CTC detecting in the predicting recurrence and metastasis of lung cancer and prognosis of patients

探讨肺癌患者循环肿瘤细胞(CTC)检测在复发转移及预后预测中的应用效果。选择71例肺癌患者设为观察组,所有患者经过化疗、手术治疗,术后3年随访。选择同期在本院体检健康者55例为对照组。采用免疫磁珠富集联合免疫荧光染色法测定两组CTC阳性表达情况,分析CTC阳性率与肺癌患者复发、转移及预后的相关性。结果显示,观察组CTC阳性率显著高于对照组;肺癌患者复发、转移与CTC阳性率呈显著正相关性;肺癌患者预后与CTC阳性率呈显著负相关性。结果提示,CTC在肺癌患者中阳性率较高,能预测患者复发、转移,有助于评估患者预后。

To investigate the detecting of circulating tumor cells(CTC)in prediction of recurrence,metastasis and prognosis in the patients with lung cancer.Seventy-one patients with lung cancer were enrolled in the observation group.All patients underwent chemotherapy and surgery,and 3 years follow-up period.55 cases with healthy physical examination at the same time served as the control group.The positive expression of CTC was detected by immunomagnetic beads enrichment combined with immunofluorescence staining.The correlation between the recurrence,metastasis and prognosis of patients with lung cancer and CTC positive rate were analyzed.The results showed,positive rate of CTC in the observation group was significantly higher than that in the control group.The positive rate of CTC and the recurrence and metastasis were positively correlated.The prognosis of lung cancer patients was negatively correlated with the positive rate of CTC.The study indicated that CTC has a high positive rate in lung cancer patients,which can predict recurrence,metastasis and assess the prognosis of patients.