IGFBP7在早期预测脓毒症急性肾损伤中作用的研究

The role of IGFBP7 in early prediction of sepsis-induced acute kidney injury

探讨胰岛素样生长因子结合蛋白7(IGFBP7)在早期预测脓毒症急性肾损伤(AKI)中的作用。选取入住本院ICU的患者97例分为脓毒症组和脓毒症AKI组,分析两组患者间尿IGFBP7水平的差异及各组不同时间点尿IGFBP7的差异,评估其在早期预测脓毒症AKI中的作用。结果显示脓毒症AKI组入住ICU当天尿IGFBP7水平高于脓毒症组(P<0.05)。随AKI各期进展血清肌酐(SCr)、尿素氮(BUN)、胱抑素C(CysC)和尿IGFBP7水平逐渐升高(P<0.05)。尿IGFBP7曲线下的面积为0.81(95%CI:0.73-0.89),优于SCr和CysC。尿IGFBP7可以作为临床诊断脓毒症AKI的敏感性指标。

To explore the role of urinary Insulin-Like Growth Factor-Binding Protein 7(IGFBP7)in early prediction of sepsis-induced Acute Kidney Injury(AKI).97 patients admitted to ICU in our hospital from September 2016 to June 2018 were selected.Clinical data were collected and divided into sepsis group and sepsis AKI group.Urinary IGFBP7 concentration was measured in all samples from different groups and at different time points.The difference of urinary IGFBP7 level among two groups was analyzed,and the difference of urinary IGFBP7 level between different time points was analyzed.The urinary IGFBP7 level of sepsis AKI group was higher than that of sepsis group on the day of ICU admission(P<0.05).The serum levels of SCr,BUN,CysC and urinary IGFBP7 level increased gradually with the progress of AKI,and there was significant difference among the stages(P<0.05).The area under the curve of urinary IGFBP7 was 0.81(95%CI:0.73-0.89).Urinary IGFBP7 has high accuracy and specificity in the early prediction of sepsis-induced AKI.It can be used as a reference index for early clinical diagnosis.