脂联素及CEA、CA125、CA199水平在胃癌患者的变化及其临床意义

Changes and Clinical Significance of Adiponectin and CEA, CA125 and CA199 Levels in Patients with Gastric Cancer

目的探讨脂联素及CEA、CA125、CA199水平在胃癌患者早期诊断中的应用价值,为临床试验提供依据。方法选取收治的胃癌患者50例作为观察组,同时选取同期行健康体检的50例健康者为对照组,同时选取50例胃炎、胃溃疡患者作为良性组;三组患者均采用电化学发光免疫分析法(ECLIA)进行血浆脂联素及血清肿瘤标志物CEA、CA125、CA199检测;对其监测结果进行分析。结果观察组患者血浆脂联素水平为(7.5±1.2)ug/mL明显低于良性组的(10.2±1.9)ug/mL及对照组的(13.6±2.0)ug/mL(P<0.05);但观察组患者血清CEA、CA125、CA199水平均明显高于对照组(P<0.05);且观察组中胃癌分级为Ⅰ-Ⅱ级患者与Ⅲ-Ⅳ级者比较,血浆脂联素及血清CEA、CA125、CA199水平均存在统计学意义(P<0.05);观察组患者肿瘤标志物CEA、CA125、CA199检测阳性率分别为54.0%、56.0%、48.0%,均明显高于对照组的20.0%、10.0%、22.0%及良性组的28.0%、28.0%、20%;差异存在统计学意义(P<0.05);四种标志物联合检测对胃癌的灵敏度及特异度均有所升高,且四种标志物联合检测对胃癌的灵敏度均明显高于单独检测(P<0.05)。结论脂联素及CEA、CA125、CA199在胃癌诊断中均可发挥一定功效。

Objective To investigate the application value of adiponectin and CEA,CA125 and CA199 levels in the early diagnosis of gastric cancer.To provide evidence for clinical trials.Methods 50 patients with gastric cancer admitted to our hospital were selected as the observation group,and 50 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group.Meanwhile,50 patients with gastritis and gastric ulcer were selected as the benign group.Electrochemical luminescent immunoassay(ECLIA)was used to detect plasma adiponectin and serum tumor markers CEA,CA125 and CA199.The monitoring results were analyzed.Results The plasma adiponectin level of the observation group was(7.5±1.2)ug/mL,significantly lower than that of the benign group(10.2±1.9)ug/mL and the control group(13.6±2.0)ug/mL(P<0.05).However,the serum levels of CEA,CA125 and CA199 in the observation group were significantly higher than those in the control group(P<0.05).And observation group of patients with gastric cancer in class forⅠ-Ⅱcompared withⅢ-Ⅳlevel,plasma adiponectin and serum CEA,CA125,CA199 levels there were statistically significant(P<0.05);The positive detection rates of tumor markers CEA,CA125 and CA199 in the observation group were 54.0%,56.0%and 48.0%,respectively,which were significantly higher than those of the control group(20.0%,10.0%and 22.0%)and the benign group(28.0%,28.0%and 20%).The difference was statistically significant(P<0.05).The sensitivity and specificity of the combined detection of the four markers for gastric cancer increased,and the sensitivity of the combined detection of the four markers for gastric cancer was significantly higher than that of the single detection(P<0.05).Conclusions Adiponectin,CEA,CA125 and CA199 can play a certain role in the diagnosis of gastric cancer and can be widely used.