淋巴细胞迁移与炎症性肠病关系的研究进展

Advance in research on the relationship between lymphocyte migration and inflammatory bowel disease

淋巴细胞迁移是近年来基础和临床研究的热点,其被认为与多种慢性病的发生有关,如类风湿关节炎、慢性幽门螺杆菌感染相关性胃炎、慢性淋巴细胞性甲状腺炎等。炎症性肠病(inflammatory bowel disease,IBD)是一种免疫异常介导的慢性炎症性肠道疾病,研究发现IBD发病亦与淋巴细胞迁移相关,其中淋巴细胞向肠道的迁移异常为其致病机制之一。本文旨在探讨淋巴细胞向肠道迁移异常与IBD发病的关系,并将近年来针对淋巴细胞迁移在IBD的靶向性治疗方面的研究作一综述。

Lymphocyte migration is a focus of basic and clinical research in recent years,which is believed to be related to the occurrence of a variety of chronic diseases,such as rheumatoid arthritis,chronic lymphocytic thyroiditis,chronic Helicobacter pylori infection-related gastritis.Researchers have found inflammatory bowel disease(IBD)is also associated with lymphocyte migration,and the aberrant migration of lymphocytes to the intestinal tract is one of the pathogenic mechanisms.This review was to investigate the relationship between aberrant migration of lymphocytes to the intestinal tract and the occurrence of IBD.