早发性卵巢功能不全患者肥胖及糖脂代谢特征

The Characteristics of Obesity and Glycolipid Metabolism in Premature Ovarian Insufficiency Patients

目的:探讨早发性卵巢功能不全(POI)患者肥胖及糖脂代谢特征。方法:选取2018年1月—2019年6月在首都医科大学附属北京妇产医院内分泌科就诊的POI患者102例,平均年龄(30.34±4.73)岁,选择同期年龄匹配的正常对照组68例,平均年龄(30.76±4.69)岁,记录研究对象的年龄、月经情况,测量其身高、体质量、腰围、臀围,测定血清基础卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、空腹血糖(FPG)、空腹胰岛素(FINS)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)和低密度脂蛋白胆固醇(LDL-c)。对POI组及正常对照组的各项指标进行比较。结果:①POI患者臀围高于正常对照组(P=0.016),2组间其他人体测量指标比较差异均无统计学意义(P>0.05)。②POI组与正常对照组全身型肥胖率(27.4%vs.23.5%)及腹型肥胖率(33.3%vs.33.8%)比较差异均无统计学意义(P>0.05)。③POI组TG、LDL-c及FINS均高于正常对照组(P<0.05),2组间TC、HDL-c、FPG及HOMA-IR比较差异无统计学意义(P>0.05)。结论:POI患者肥胖率与正常对照组相似,而部分糖脂代谢指标不同于年龄匹配的正常人群,临床工作中对POI患者诊疗时应进行全面评估。

Objective:To explore the characteristics of obesity and glycolipid metabolism in premature ovarian insufficiency(POI)patients.Methods:102 POI patients with age 30.34±4.73 years and 68 healthy age-matched women(control group)with age 30.76±4.69 years,who came to Department of Gynecological Endocrinology in Beijing Obstetrics and Gynecology Hospital between January 2018 and June 2019,were recruited.Age and menstruation of these patients were recorded.Body height,body weight,waist circumference,hip circumference,basal follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),fasting plasma glucose(FPG),fasting insulin(FINS)and blood lipids(total cholesterol,triglyceride,high density lipoprotein-cholesterol and low density lipoprotein-cholesterol)were measured.The indices between POI patients and control group were compared.Results:①The hip circumference of POI patients was higher than control group(P=0.016).But there were no significant differences in other anthropometric indices between the two groups(P>0.05).②The comparison of the prevalence of overall obesity(27.4%vs.23.5%)and abdominal obesity(33.3%vs.33.8%)between POI patients and control group had no significant differences(P>0.05).③The level of TG,LDL-c and FINS in POI patients were higher than control group(P<0.05).While there were no significant differences in TC,HDL-c,FPG and HOMA-IR between the two groups(P>0.05).Conclusions:The prevalence of obesity in POI patients was similar to control group.While some of the glycolipid metabolism indices are different between POI patients and control group.So it is necessary to give a comprehensive assessment of POI patients in clinical work.