21例洛索洛芬严重不良反应分析

Analysis of 21 Cases of Severe Adverse Reactions Induced by Loxoprofen

目的探讨洛索洛芬严重不良反应特点,为临床合理用药提供参考。方法以“洛索洛芬”和“Loxoprofen”为关键词,在中国知网、万方医学信息查询系统、维普医药信息资源系统、PubMed等数据库检索2000年1月—2018年12月洛索洛芬严重不良反应报道,并对检索到的严重不良反应文献进行统计分析。结果共检索到洛索洛芬严重不良反应文献20篇,涉及患者21例,其中男5例(23.81%),女16例(76.19%)。患者年龄26~87岁,平均(53.19±19.21)岁。严重不良反应发生时间30 min^30 d。不良反应用药情况:单独用药9例(42.86%),合并用药12例(57.14%)。累及器官系统较多,变态反应和消化系统各4例,泌尿系统、神经系统、心血管系统各3例,呼吸系统2例,血液系统1例,其他4例。由于干预措施及时正确,转归情况较好,无致死病例。结论洛索洛芬严重不良反应发现病例数较少,但仍需加强对该药不良反应的关注,避免或减少不良反应发生。

Objective To explore the clinical characteristics of severe adverse reactions of loxoprofen,and provide reference for rational drug use in clinical practice.Methods Severe adverse reactions of loxoprofen from January 2000 to December 2018 were retrieved through the key words“loxoprofen”(both in Chinese and English)in electronic databases,including CNKI,Wanfang,VIP and PubMed.The retrieved severe adverse reactions were statistically analyzed.Results A total of 21 cases in 20 literatures on severe adverse reactions of loxoprofen were retrieved,including 5 males(23.81%)and 16 females(76.19%).The minimum age of the patients was 26 and the maximum age was 87(the average age was 53.19±19.21).The shortest occurrence time of severe adverse reactions was 30 minutes and the longest was 30 days.Nine cases(42.86%)were treated alone and 12 cases(57.14%)were combined with other drugs.There were many organ systems involved,allergic reactions in 4 cases,digestive system in 4 cases,urinary system in 3 cases,nervous system in 3 cases,cardiovascular system in 3 cases,respiratory system in 2 cases,blood system in 1 case and other 4 cases.Due to the timely and correct intervention measures,the prognosis was good and no fatal cases occurred.Conclusion The serious adverse reactions of loxoprofen is relatively rare,but still need to pay more attention to avoid loxoprofen-induced adverse reactions,so as to ensure the quality of life and safety of patients.