泰地罗新注射液的急性毒性试验研究

Study on Acute Toxiciy of tildipirosin injection

为了考察泰地罗新注射液的安全性,分别对SPF级SD大鼠和ICR小鼠进行腹腔注射给药的急性毒性试验。随机将60只大鼠分为6组,每组10只,其中雌雄各半,进行急性毒性试验考察;随机将60只小鼠分为6组,每组10只,其中雌雄各半,进行急性毒性试验考察。结果表明:泰地罗新注射液大鼠腹腔注射LD50为298.40 mg/kg,LD5095%的可信限为279.60~318.80 mg/kg;泰地罗新注射液小鼠腹腔注射LD50为190.08 mg/kg,LD5095%的可信限为164.80~220.80 mg/kg。根据兽药指导原则急性毒性试验剂量分级标准,该产品属于中等毒级。

In order to investigate the safety of the tildipirosin injection,acute toxicity test was carried out on SPF grade SD rats and ICR mice.Sixty SD rats were randomly divided into six groups,10 SD rats in each group,half male and female,and acute toxicity test was carried out.Sixty ICR mice were randomly divided into six groups,10 ICR mice in each group,half male and female,and acute toxicity test was carried out.The results showed that the LD50 of the tildipirosin injection was 298.40 mg/kg in rats,and the 95%confidence interval of LD50 was 279.60~318.80 mg/kg;the LD50 of the tildipirosin injection was 298.40 mg/kg in mice,and the 95% confidence interval of LD50 was 279.60~318.80 mg/kg.According to the veterinary drug guidelines of acute toxicity test does grading standards,the product is of medium toxic grade.