补肾祛斑汤治疗黄褐斑临床观察

Analysis of the application value of Bushen Quban Decoction in the treatment of chloasma

目的黄褐斑是一种常见的难治性皮肤病,治疗手段匮乏。本研究探讨补肾祛斑汤治疗黄褐斑的临床效果。方法选取2017-04-01-2018-04-01辽宁中医药大学附属医院收治的80例黄褐斑患者作为研究对象,按照年龄、病程组间均衡的原则选择观察组与对照组,各40例。对照组给予维生素C及维生素E药物治疗;观察组给予补肾祛斑汤治疗。两组均连续治疗90d。对比分析两组患者的临床疗效、治疗前后血清SP和MSH指标水平及患者皮肤病生活质量。结果观察组临床有效率为92.50%,高于对照组的75%,χ2=4.501,P=0.034。治疗后观察组血清SP水平为(16.54±1.48)ng/L,低于对照组的(34.69±3.18)ng/L,t=32.726,P<0.001;MSH水平为(364.28±34.23)pmol/mL,低于对照组的(385.25±25.91)pmol/mL,t=3.089,P=0.003。治疗后观察组患者生理领域评分为(44.81±4.54)分,高于对照组的(40.54±4.43)分,t=4.257,P<0.001;心理领域评分为(73.62±10.84)分,高于对照组的(63.55±9.57)分,t=4.404,P<0.001;症状领域评分为(65.42±8.84)分,高于对照组的(55.61±8.54)分,t=5.047,P<0.001;社会关系领域评分为(45.57±7.36)分,高于对照组的(39.14±6.73)分,t=4.077,P<0.001;环境领域评分为(108.12±11.45)分,高于对照组的(97.48±10.88)分,t=4.260,P<0.001;精神支柱评分为(18.25±3.58)分,高于对照组的(15.42±3.82)分,t=3.418,P<0.001;生活质量总分为(21.54±3.68)分,高于对照组的(16.16±3.47)分,t=6.727,P<0.001。结论补肾祛斑汤治疗黄褐斑临床疗效显著,可有效改善患者的生活质量、调节血清神经肽水平,发挥祛斑悦颜的效果。

OBJECTIVE Melasma is a common refractory skin disease,and treatment methods are lacking.The purpose of this study is to analyze the value of Bushen Quban Decoction in the treatment of melasma.METHODS From April 1,2017 to April 1,2018,80 patients with chloasma treated in our hospital were enrolled in the study.The patients were divided into two groups according to different clinical treatment methods,40 in the control group and the experimental group.The control group received clinical vitamin C and vitamin E drugs,and the experimental group was treated with Bushen Quban Decoction.The two groups were treated for 90 consecutive days.The clinical efficacy of the two groups of patients,the levels of serum SP,M,SH before and after treatment,and the quality of life of patients with skin diseases were compared.RESULTS The clinical effective rate of the observation group was 92.50%,which was higher than 75%of the control group,χ~2=4.501,P=0.034.The serum SP level of the observation group after treatment was(16.54±1.48)ng/L,which was lower than that of the control group(34.69±3.18)ng/L,t=32.726,P<0.001.The serum MSH level in the observation group after treatment was(364.28±34.23)pmol/ml,which was lower than that in the control group(385.25±25.91)pmol/ml,t=3.089,P=0.003.The physiological field score of the observation group after treatment(44.81±4.54),higher than the control group(40.54±4.43),t=4.257,P<0.001.The psychological field score of the observation group after treatment was(73.62±10.84),higher than that of the control group(63.55±9.57),t=4.404,P<0.001.After treatment,the observation group’s symptom area score(65.42±8.84)was higher than that of the control group(55.61±8.54),t=5.047,P<0.001.The post-treatment observation group’s social relationship area score was(45.57±7.36),higher than the control group(39.14±6.73),t=4.077,P<0.001.The environmental field score of the observation group after treatment was(108.12±11.45),higher than the control group(97.48±10.88),t=4.260,P<0.001.The post-treatment observation group’s mental pillar score was(18.25±3.58),higher than the control group(15.42±3.82),t=3.418,P<0.001.The total quality of life score of the observation group after treatment was(21.54±3.68),which was higher than that in the control group(16.16±3.47),t=6.727,P<0.001.CONCLUSION Through the treatment of patients with chloasma,the treatment of Bushen Quban Decoction can achieve significant clinical application,not only can effectively improve the quality of life of patients,but also can regulate the plasma neuropeptide levels of patients,and play the role of removiy beverage.