FABP2 rs1799883基因多态性与非乙醇性脂肪性肝病及冠心病的相关性

ASSOCIATION OF FABP2 rs1799883 GENE POLYMORPHISM WITH NONALCOHOLIC FATTY LIVER DISEASE AND CORONARY ARTERY DISEASE IN THE CHINESE HAN POPULATION IN QINGDAO,CHINA

目的探讨青岛汉族人群中FABP2 rs1799883基因多态性与非乙醇性脂肪性肝病(NAFLD)以及冠状动脉粥样硬化性心脏病(CAD)的相关性。方法纳入在青岛市市立医院就诊的296例住院病人,分为NAFLD组、CAD组、NAFLD合并CAD(合并组),以104名健康体检者作为对照组。采集临床信息,同时用聚合酶链反应(PCR)方法和质谱测序进行基因型检测。采用非条件Logistic回归模型分析基因型和等位基因与患病风险的关系。结果FABP2 rs1799883的基因型分布在NAFLD组与对照组、合并组与对照组、合并组与NAFLD组间差异均无统计学意义,而在CAD组与对照组间差异有统计学意义(χ^2=6.495,P<0.05)。4组FABP2 rs1799883等位基因频率比较差异均无统计学意义(P>0.05)。Logistic回归分析显示,FABP2 rs1799883 CT+TT基因型与CAD的发病风险显著相关,是CAD的保护因素(OR=0.50,95%CI=0.29~0.87,P<0.05);对性别、年龄进行校正后,CT+TT基因型仍然与CAD发病风险相关(OR=0.46,95%CI=0.24~0.90,P<0.05)。结论在青岛汉族人群中,FABP2 rs1799883基因多态性与NAFLD以及NAFLD合并CAD的发病风险无明显相关性,但其CT+TT基因型与CAD的发病风险相关,是CAD的一种保护性因素。

Objective To investigate the association of FABP2 rs1799883 gene polymorphism with nonalcoholic fatty liver disease(NAFLD)and coronary artery disease(CAD)in the Chinese Han population in Qingdao,China.Methods A total of 296 inpatients admitted to Qingdao Municipal Hospital were included and divided into NAFLD group,CAD group,and NAFLD with CAD group.Another 104 healthy individuals who underwent physical examination were included as control group.After collection of clinical information,PCR and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were used to determine the genotype of FABP2 rs1799883.The unconditional Logistic regression model was used to analyze the relationship of genotype and allele with disease risk.Results The genotype distribution of FABP2 rs1799883 was not significantly different between the NAFLD group and the control group,between the NAFLD with CAD group and the control group,and between the NAFLD with CAD group and the NAFLD group,but was significantly different between the CAD group and the control group(χ^2=6.495,P<0.05).The allele frequency of FABP2 rs1799883 showed no significant difference between the four groups(P>0.05).The logistic regression analysis showed that FABP2 rs1799883 CT+TT genotype was significantly associated with the risk of CAD and was a protective factor against CAD(OR=0.50,95%CI=0.29-0.87,P<0.05).After adjustment for sex and age,CT+TT genotype was still associated with the risk of CAD(OR=0.46,95%CI=0.24-0.90,P<0.05).Conclusion Among the Chinese Han population in Qingdao,the FABP2 rs1799883 gene polymorphism is not significantly associated with the risk of NAFLD or NAFLD with CAD,but its CT+TT genotype is associated with the risk of CAD and is a protective factor against CAD.