慢性阻塞性肺疾病与肌少症相关性的研究进展

Research progress on the correlation between chronic obstructive pulmonary disease and sarcopenia

随着人口老龄化,慢性阻塞性肺疾病(COPD)与肌少症等增龄相关性疾病的发病率增加。越来越多的研究显示,COPD与肌少症之间存在着密切的联系。COPD患者常见有股四头肌无力、萎缩和纤维类型转换;同时呼吸肌也发生适应性改变,导致患者呼吸功能不全.活动受限,生活质量下降,住院率与病死率增加。但是目前COPD与肌少症的相互作用机制尚未完全明确,尤其是临床医生对COPD骨骼肌功能障碍缺乏早期识别与干预。本文将对COPD与肌少症的发病情况、两者的相互作用机制及治疗进展进行综述.以供临床参考。

As the population ages,the incidences of age-related diseases such as chronic obstructive pulmonary disease(COPD)and sarcopenia are on the rise.A growing number of studies have found that there is a close relationship between COPD and sarcopenia.Quadriceps weakness,atrophy,and fiber type conversion of skeletal muscles are common in patients with COPD.At the same time,respiratory musecles also have adaptive changes,resulting in limited mobility,decreased quality of life and increased hospitalization rates and mortality.However.mechanisms underlying the interaction between COPD and sarcopenia have not been fully illuminated.Moreover.clinicians usually fail to make early identification and start intervention for COPD-related skeletal muscle dysfunction.This article reviews progress on the epidemiology,mechanisms linking the two conditions and treatment of COPD-related sarcopenia avS a reference for clinical practice.