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牙周炎与阿尔茨海默病双向关系研究

Study on the two-way relationship between periodontitis and Alzheimer's disease
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摘要 牙周炎是发生于牙周支持组织的炎症性、感染性疾病,随着牙周医学的发展,牙周炎与阿尔茨海默病的相关性逐渐成为研究热点。阿尔茨海默病是老年人最常见的神经系统退行性变疾病,发病机制较为复杂,已有临床研究发现牙周炎与阿尔茨海默病密切相关。该文就牙周炎与阿尔茨海默病在流行病学、疾病发病机制与疾病治疗上的双向关系进行综述。 Periodontitis is an inflammatory and infectious disease that occurs in the periodontal support tissue.With the development of periodontal medicine,the correlation between periodontitis and Alzheimer's disease has gradually become a research focus.Alzheimer's disease is the most common neurological degenerative disease with complicated pathogenesis occurring in the elderly.Clinical studies have found that periodontitis is closely related to Alzheimer's disease.This article will review the two-way relationship between periodontitis and Alzheimer's disease in epidemiology,pathogenesis and treatment.
作者 沈慧 宋忠臣 SHEN Hui;SONG Zhongchen(Department of Periodontology,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)
出处 《口腔医学》 CAS 2020年第9期839-842,共4页 Stomatology
基金 国家自然科学基金(81971299,81670992)。
关键词 牙周炎 阿尔茨海默病 牙龈卟啉单胞菌 脂多糖 periodontitis Alzheimer’s disease P.gingivalis LPS
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