结直肠癌中Toll样受体介导的宿主免疫反应与肠道微生物群相互作用机制的研究进展

Advances in the interaction of Toll-like receptors mediated hostimmune response with intestinal microbiota in colorectal cancer

结直肠癌是全世界发病率第二的恶性肿瘤,尽管人们发现多种影响结直肠癌发生及发展的因素,但确切的机制仍不明确。近年来关于肠道微生物群与宿主免疫反应的研究越来越多,逐渐意识到肠道微生物群相关的宿主免疫反应在结直肠癌的起源和进展中存在重要的作用。以下将对肠道微生物群调节宿主免疫反应、Toll样受体参与肠道微生物群-宿主免疫反应、基于Toll样受体的免疫治疗等作一综述。

Colorectal cancer is the second incidence of malignant tumor in the world.Although many factors have been found to affect the occurrence and development of colorectal cancer,the mechanism is still unclear.In recent years.There have been more and more studies on intestinal microbiota and host immune response.The host immune response related to intestinal microbiota plays an important role in the origin and progress of colorectal cancer.The intestinal microbiota regulating host immune response,Toll-like receptors participating in intestinal microbiota-host immune response,and Toll-like receptor-based immunotherapy were reviewed.