益气润肠法治疗气虚型慢传输型便秘40例临床观察

Clinical effect of Qi-tonifying and intestine-moistening therapy in treatment of slow transit constipation with Qi deficiency:An analysis of 40 cases

目的:观察益气润肠法治疗气虚型慢传输型便秘(STC)的临床疗效。方法:将80例气虚型STC患者随机分为治疗组和对照组,每组各40例。治疗组采用益气润肠法治疗,对照组予枸橼酸莫沙必利片和双歧杆菌四联活菌片口服、0.9%氯化钠注射液直肠滴入治疗。对比2组综合疗效、治疗前后主要证候积分和治疗结束后3个月的复发率。结果:总有效率治疗组为95.0%(38/40),明显高于对照组的85.0%(34/40),2组比较,差异有统计学意义(P<0.05)。治疗后,2组排便间隔时间、排便困难、粪便性状、排便时间、腹胀或腹痛评分均较治疗前有所改善,且治疗组改善更明显,差异均有统计学意义(P<0.05)。2组随访复发率治疗组为12.5%(5/40),明显低于对照组的67.5%(27/40),2组比较,差异有统计学意义(P<0.05)。结论:与西医治疗相比,益气润肠法治疗STC患者症状体征改善更明显,疗效更确切,复发率更低。

Objective:To investigate the clinical effect of Qi-tonifying and intestine-moistening therapy in the treatment of slow transit constipation(STC)with Qi deficiency.Methods:A total of 80 patients with STC with Qi deficiency were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the treatment group were given Qi-tonifying and intestine-moistening therapy,and those in the control group were given oral mosapride citrate tablets and Bifidobacterium tetravaccine tablets(live)combined with the rectal dripping of 0.9%sodium chloride injection.The two groups were compared in terms of overall response,syndrome scores before and after treatment,and recurrence rate at 3 months after treatment.Results:The treatment group had a significantly higher overall response rate than the control group[95.0%(38/40)vs 85.0%(34/40),P<0.05].After treatment,both groups had significant improvements in defecation interval,difficult defecation,stool form,time to first defecation,and score of abdominal distension or abdominal pain,and the treatment group had significantly greater improvements than the control group(P<0.05).During follow-up,the treatment group had a significantly lower recurrence rate than the control group[12.5%(5/40)vs 67.5%(27/40),P<0.05].Conclusion:Compared with Western medicine treatment,Qi-tonifying and intestine-moistening therapy helps to achieve a better improvement in symptoms and signs and has a better clinical effect with a lower recurrence rate.