复方芪苓配方颗粒对合并高尿酸血症冠心病患者动脉粥样硬化斑块稳定性的影响

Effect of Compound Qiling Dispensing Granules on Stability of Atherosclerotic Plaque in Patients with Coronary Heart Disease Complicated with Hyperuricemia

目的:探讨复方芪苓配方颗粒对合并高尿酸血症冠心病患者动脉粥样硬化斑块稳定性的影响。方法:将合并高尿酸血症冠心病心绞痛患者102例,采取随机数字表法将患者分为对照组和观察组,各51例。对照组参照指南给予冠心病心绞痛常规药物治疗,观察组在对照组治疗基础上给予复方芪苓配方颗粒治疗。2组连续治疗12周。比较2组临床症状评分、血尿酸水平、生活质量评分以及动脉粥样硬化斑块稳定性。结果:治疗后,2组临床症状评分、血尿酸水平降低(P<0.01);观察组治疗后临床症状评分、血尿酸水平低于对照组(P<0.01)。治疗后,2组西雅图心绞痛量表(SAQ)各指标评分增加(P<0.01);观察组治疗后SAQ指标评分高于对照组(P<0.01)。治疗后,2组血清基质金属蛋白酶-9(MMP-9)、细胞间黏附分子-1(ICAM-1)、脂蛋白磷脂酶A2(Lp-PLA2)、氧化低密度脂蛋白(OxLDL)减少(P<0.01);观察组血清MMP-9、ICAM-1、Lp-PLA2、OxLDL少于对照组(P<0.01)。结论:复方芪苓配方颗粒可改善合并高尿酸血症的冠心病患者的临床症状和血尿酸水平,且具有稳定动脉粥样硬化斑块的作用。

Objective:To investigate the effect of compound Qiling dispensing granules on the stability of atherosclerotic plaque in patients with coronary heart disease complicated with hyperuricemia. Methods:A total of 102 cases of patients with angina pectoris complicated with hyperuricemia were divided into the control group and the observation group according to the random number table method, 51 cases in each group. The control group was treated with routine medicine for angina pectoris according to the guideline, and the observation group was additionally treated with compound Qiling dispensing granules based on the treatment of the control group. Both groups were treated for 12 weeks. The scores of clinical symptoms and quality of life, levels of serum uric acid, and stability of atherosclerotic plaque in the two groups were compared. Results:After treatment,clinical symptom scores and serum uric acid levels in the two groups were decreased(P<0.01);the clinical symptom score and serum uric acid level in the observation group were lower than those in the control group(P<0.01). After treatment, the scores of each index in Seattle Angina Questionnaire(SAQ) of the two groups were increased(P<0.01);the SAQ scores in the observation group were higher than those in the control group(P<0.01). After treatment, the levels of matrix metalloproteinase-9(MMP-9), intercellular adhesion molecule-1(ICAM-1), lipoproteinphospholipase A2(Lp-PLA2) and oxidized low density lipoprotein(OxLDL) in serum in the two groups were decreased(P<0.01);the levels of MMP-9,ICAM-1,Lp-PLA2 and OxLDL in serum in the observation group were lower than those in the control group(P<0.01). Conclusion: Compound Qiling dispensing granules for patients with coronary heart disease complicated with hyperuricemia can improve their clinical symptoms and serum uric acid levels,with the effect of stabilizing atherosclerotic plaque.