摘要
目的:观察夏枯草胶囊辅助治疗桥本甲状腺炎的临床疗效。方法:选取桥本甲状腺炎患者62例,按随机数字表法分为对照组和观察组各31例。对照组给予左甲状腺素钠片治疗,观察组在对照组基础上给予夏枯草胶囊。比较2组治疗前后相关甲状腺抗体指标[甲状腺球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)]、甲状腺激素指标[游离甲状腺素T3(FT3)、游离甲状腺素T4 (FT4)及促甲状腺激素(TSH)]、血清细胞因子[白细胞介素-1 (IL-1)、白细胞介素-6 (IL-6)及肿瘤坏死因子-α(TNF-α)]水平的变化情况,观察2组不良反应发生情况。结果:治疗前,2组TG-Ab及TPO-Ab水平比较,差异无统计学意义(P>0.05)。治疗后,2组TG-Ab及TPO-Ab水平较治疗前降低,且观察组TG-Ab及TPO-Ab水平低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组FT3、FT4及TSH水平比较,差异无统计学意义(P>0.05)。治疗后,2组FT3及FT4水平较治疗前升高,TSH水平较治疗前降低;且观察组FT3及FT4水平高于对照组,TSH水平低于对照组;差异均有统计学意义(P<0.05)。治疗前,2组IL-1、IL-6及TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,2组IL-1、IL-6及TNF-α水平较治疗前降低,且观察组IL-1、IL-6及TNF-α水平低于对照组,差异均有统计学意义(P<0.05)。结论:夏枯草胶囊辅助治疗桥本甲状腺炎患者,可降低TG-Ab、TPO-Ab、TSH水平,升高FT3、FT4水平,同时还能有效降低患者体内血清中相关细胞因子,且安全性高。
Objective: To observe the clinical effect of Xiakucao capsules in the adjuvant treatment of Hashimoto’s thyroiditis. Methods:A total of 62 patients with Hashimoto’s thyroiditis were selected and divided into the control group and the observation group according to random number table method,31 cases in each group. The control group was treated with levothyroxine sodium tablets,and the observation group was additionally given Xiakucao capsules based on the treatment of the control group. Before and after treatment, the changes in levels of thyroid antibody indexes including thyroglobulin antibody(TG-Ab), thyroid peroxidase antibody(TPO-Ab), thyroid hormone indexes including free thyroxine T3(FT3), free thyroxine T4(FT4),thyroid-stimulating hormone(TSH),serum cytokines including interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) were compared in the two groups;the incidence of adverse reactions in both groups was observed. Results:Before treatment,there was no significant difference in the comparison of the levels of TG-Ab and TPO-Ab between the two groups(P>0.05). After treatment, the levels of TG-Ab and TPO-Ab in the two groups were decreased when compared with those before treatment,and the above two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). Before treatment,there was no significant difference in the comparison of the levels of FT3,FT4 and TSH between the two groups(P>0.05). After treatment,the levels of FT3 and FT4 in both groups were increased when compared with those before treatment,while the TSH levels were decreased;the levels of FT3 and FT4 in the observation group were higher than those in the control group,while the TSH level was lower,differences being significant(P<0.05). Before treatment,there was no significant difference in the comparison of the levels of IL-1, IL-6 and TNF-α between the two groups(P>0.05). After treatment, the levels of IL-1, IL-6 and TNF-α were decreased when compared with those before treatment,and the above three levels in the observation group were lower than those in the control group, differences being significant(P<0.05). Conclusion: In the adjuvant treatment of Hashimoto’s thyroiditis, Xiakucao capsules can reduce levels of TG-Ab, TPO-Ab and TSH, increase levels of FT3 and FT4, and effectively reduce serum cytokines,with great safety.
出处
《新中医》
CAS
2020年第19期91-94,共4页
New Chinese Medicine
基金
河南省中医药科学研究专项课题(2017ZY2051)。