拉贝洛尔联合硫酸镁注射液治疗妊娠高血压综合征的临床研究

Clinical trial of labetalol combined with magnesium sulfate injection in the treatment of pregnancy-induced hypertension syndrome

目的探讨拉贝洛尔联合硫酸镁治疗妊娠高血压综合征的效果及对外周血白细胞介素-6(IL-6)的影响。方法用随机区组设计将纳入患者分为试验组和对照组各50例,试验组用拉贝洛尔+硫酸镁治疗,对照组仅给予硫酸镁。对比2组治疗前后的收缩压(SBP)、舒张压(DBP)、脉压差和24 h尿蛋白;统计2组的不良妊娠结局。结果治疗后,试验组和对照组的SBP分别为(133.28±8.03)和(136.90±7.43)mmHg;这2组的DBP分别为(81.85±6.46)和(85.36±7.18)mmHg;这2组的24 h尿蛋白分别为(763.28±155.07)和(863.72±167.64)mg,组间比较,上述指标的差异均有统计学意义(均P<0.05)。试验组和对照组的IL-6分别为(27.11±5.52)和(31.54±6.28)pg·mL^-1,组间比较差异有统计学意义(P<0.05)。经治疗,试验组的宫内窘迫率6.00%(3例/50例)、新生儿窒息率26.00%(13例/50例);对照组分别为22.00%(11例/50例)和22.00%(11例/50例),组间比较差异均有统计学意义(均P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠高血压综合征的效果较单用硫酸镁更好,能有效调节血清IL-6水平,降低不良妊娠发生率。

Objective To investigate the effect of labetalol combined with magnesium sulfate on pregnancy-induced hypertension syndrome and the influence of peripheral blood interleukin-6(IL-6).Methods Pregnant women with pregnancy-induced hypertension syndrome were divided into two groups:treatment group and control group with 50 cases each.The treatment group was treated with labetalol+magnesium sulfate,and the control group was given only magnesium sulfate.The systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure difference,and 24 h urine protein before and after treatment in the two groups were compared.The adverse pregnancy outcomes of the two groups were counted.Results After treatment,the SBP in treatment group and control group were(133.28±8.03)and(136.90±7.43)mmHg,respectively;the DBP in the two groups were(81.85±6.46)and(85.36±7.18)mmHg,respectively;the urine protein in 24 h in the two groups were(763.28±155.07)and(863.72±167.64)mg,respectively;and the difference of the factors were statistically significant(all P<0.05).The IL-6 in treatment group and control group were(27.11±5.52)and(31.54±6.28)pg·mL^-1,the difference was statistically significant(P>0.05).After treatment,the intrauterine distress rate in treatment group was 6.00%(3 cases/50 cases),the neonatal asphyxia rate was 26.00%(13 cases/50 cases);and the control group was 22.00%(11 cases/50 cases),22.00%(11 cases/50 cases);the difference of the indicators between the two groups were statistically significant(all P<0.05).Conclusion Labetalol combined with magnesium sulfate is more effective in treating pregnancy-induced hypertension syndrome than magnesium sulfate alone.It can effectively regulate the levels of serum IL-6 and reduce the incidence of adverse pregnancy.