189例替格瑞洛药物不良反应的特点分析

Analysis of the characteristics of adverse drug reactions of ticagrelor in 189 cases

目的分析替格瑞洛药物不良反应(ADRs)发生的特征及可能的影响因素。方法检索中国知网、万方、维普等数据库中关于替格瑞洛ADRs的文献进行统计分析,检索时间截至2019年12月。用回顾性研究方法对患者年龄、性别、用药情况以及ADRs的发生时间、临床表现、处理与转归等指标进行统计分析。结果共纳入159例病例,189例次ADRs;以男性为主(117例,75%);年龄≥51岁有122例(76.73%);累及的器官或系统主要有呼吸系统(91例,48.14%)、皮肤及皮下组织(41例,21.69%)和消化系统(38例,20.11%)等。结论在应用替格瑞洛的过程中应注意加强监测,以减少ADRs的发生。

Objective To analyze the characteristics and possible influencing factors of the occurrence of adverse drug reactions(ADRs)induced by ticagrelor in order to provide references for safe and rational medication.Methods CNKI,Wanfang and VIP databases were searched for ADRs induced by ticagrelor to December 2019.Retrospective study was used to analyze the patient’s age,gender,medication status,occurrence time,clinical manifestation,treatment and outcome of ADRs.Results A total of 159 cases and 189 times of adverse drug reactions were included.There were 117 male patients accounting for 75.0%.Aged patients over 51 years-old showed a higher incidence(n=122,76.73%).The ADRs induced by ticagrelor were the respiratory system(n=91,48.14%),skin and subcutaneous tissue(n=41,21.69%),digestive system(n=38,20.11%).Conclusion In order to reduce the occurrence of ADRs,we should pay attention to strengthen the monitoring during the application of tegrarol.