补肾活血方对创伤骨折后骨质疏松症的疗效及作用机制探讨

The effects and mechanism of the Bushen Huoxue prescription on osteoporosis after traumatic fracture

目的:探讨补肾活血方对创伤骨折后骨质疏松症的疗效及作用机制。方法:将本院收治的90例创伤骨折后骨质疏松症患者随机分为对照组和观察组,每组45例,对照组给予碳酸钙D3咀嚼片口服,观察组在对照组基础上给予补肾活血方治疗,比较两组患者的临床疗效、骨密度变化、骨折愈合时间、外固定拆除时间以及血清钙、血清磷、骨源性碱性磷酸酶(BALP)、血清骨钙素(Bone Alkaline Phosphatase,BGP)。结果:观察组总有效率高于对照组(χ^2=6.381,P=0.015);治疗前两组患者骨密度比较(P>0.05),治疗后两组患者骨密度均明显升高,且观察组优于对照组(P<0.05);对照组骨折愈合时间、外固定拆除时间明显的长于观察组(P<0.05);治疗前两组血清钙、血清磷、BALP、BGP水平比较,P>0.05。治疗后血清钙、血清磷、BALP、BGP水平均升高,且观察组优于对照组(P<0.05)。结论:补肾活血方对创伤骨折后骨质疏松症患者具有较好的临床疗效,可以有效地改善患者骨质钙盐代谢的相关血清生化指标,且具有良好的安全性,值得临床上推广使用。

Objective:To explore the effect and mechanism of the Bushen Huoxue prescription(补肾活血方)on osteoporosis after traumatic fracture.Methods:90 patients were randomly divided into the control group and observation group,45 cases in each.The control group was given calcium carbonate D3 chewable tablet orally,and the observation group was given the Bushen Huoxue prescription more.Results:The total efficiency in the observation group was higher than the control group(χ^2=6.381,P=0.015).After treatment,the BMD in groups was significantly higher than before treatment,and that in the observation group was higher than the control group(P<0.05).The time of fracture healing and removal of external fixation in the control group was significantly longer than the observation group(P<0.05).The serum calcium,serum phosphorus,BALP,BGP in two groups were increased than before treatment,and those in the observation group was better than the control group(P<0.05).Conclusion:The Bushen Huoxue prescription shows a good effect on osteoporosis after trauma fracture,can effectively improve the serum biochemical indexes related to the metabolism of bone calcium salt,with good safety,and is worthy of clinical application.