临床药师参与1例药物相互作用致低血糖实践

Clinical Pharmacist Participating in the Practice of Drug Interaction Resulting in Hypoglycemia in 1 Case

目的探讨临床药师在干预潜在药物相互作用中的作用。方法临床药师参与1例2型糖尿病并冠状动脉粥样硬化性心脏病突发低血糖的治疗过程,通过对治疗方案的评价,分析患者突发低血糖为硫酸氢氯吡格雷片与瑞格列奈片的相互作用所致,提出用药建议。结果医师采纳临床药师建议,调整药物治疗方案后未再出现低血糖反应。结论联合用药在临床药物治疗过程中普遍存在,临床药师应熟悉药物间可能存在的药物相互作用,从而减少或避免药品不良反应发生,保证患者的用药安全、有效。

Objective To investigate the role of clinical pharmacists in interfering with potential drug interactions.Methods Clinical pharmacist participated in the treatment of acute hypoglycemia in 1 patient with coronary atherosclerotic heart disease and type 2 diabetes mellitus.Through the evaluation of the whole treatment program,the author analyzed that the reason of the sudden hypoglycemia in patients was caused by the interaction between clopidogrel bisulfate tablet and regrainide tablet,and proposed the next treatment measures based on the comprehensive consideration of the patients’basic diseases.Results The physician followed the advice of the clinical pharmacist and hypoglycemia did not recur after the adjustment of medication regimen.Conclusion Combination drug use is common in clinical drug treatment.Clinical pharmacists should be familiar with the possible drug interactions between drugs,so as to reduce or avoid the occurrence of adverse reactions and ensure the safety and efficacy of drug use.