高血压病患者内皮素、一氧化氮测定的临床意义

The Significance of detecting the ET and NO levels in Hypertension patients

目的 :了解内皮素、一氧化氮在高血压发病中的作用。方法 :放射免疫分析法检测 94例高血压病患者血浆中内皮素 (ET)含量 ,并与 35名正常人作对照。同时采用Greiss法测定亚硝酸盐及硝酸盐以间接测定一氧化氮 (NO)含量。结果 :高血压病患者血ET水平显著地高于正常人 (P <0 .0 1) ,而NO水平则明显下降 (P <0 .0 1) ,且与病情的程度有一定的关系。结论 :测定高血压病血ET和NO水平的变化与高血压的发生和发展密切相关。

Objective: In order to study the role of plasma ET and NO in the cause of Hypertension patients. Methods: The Concentrations of plasma ET was detected by radioimmunoassay in 94 patients with Hypertension and 35 normal controls. Meantime plasma NO 2 - / NO 3 - levels, the stable metabolic end product of NO was determined with Greiss determination. Results: The plasma ET levels in patients with Hypertension were significantly higher than those in normal control (P<0.01).While plasma NO levels were decreased markly(P<0.01). The score index of Hypertension had significant correlation with the levels of plasma ET?NO. Conclusion: It was shows that the ET NO are concened with the Occurrence and development of the Hypertension patients.