miR-378在宫颈癌浸润和转移中的研究进展

Research progress of the role of miR-378 in invasion and metastasis of cervical cancer

宫颈癌是女性常见的生殖系统恶性肿瘤之一,尽管早期筛查率大幅度提升,宫颈癌疫苗的上市也起到了较好的预防作用,但其发病率仍居女性恶性肿瘤第二位,且逐渐倾向于年轻女性.宫颈癌的病因主要是高危型人乳头瘤病毒持续感染,肿瘤的浸润和转移仍然是有效治疗宫颈癌的巨大障碍.研究宫颈癌浸润转移的分子机制,可以为宫颈癌治疗提供新的靶点.本研究就miR-378与宫颈癌浸润和转移的关系进行综述,以期为预防和治疗宫颈癌提供更有效的方法.

Cervical cancer is one of the most common malignant tumors of the reproductive system in women.Despite a significant increase in early screening rates and a better preventive effect on the introduction of cervical cancer vaccine,the incidence is still the second highest in female malignant tumors,and gradually tends to young women.The major cause of disease is the persistent infection of the high-risk HPV virus,tumor invasion and metasta-sis is still a huge obstacle to effective treatment of cervical cancer.Stupying the molecular mechanism of the metastasis and invasion of cervical cancer may prov ide a novel therapeutie target for the treatment of cervical cancer.This paper reviews the relationship between miR-378 and the invasion and metastasis of cervical cancer,in order to provide more effective methods for the prevention and treatment of cervical cancer.