HBV相关肝细胞癌的发生机制

Pathogenesis of hepatitis B virus-related hepatocellular carcinoma

肝细胞癌是最常见的致死性肿瘤之一。慢性HBV感染是肝细胞癌的主要危险因素。介绍了HBV相关肝细胞癌的具体机制,包括HBV X蛋白、免疫失衡以及病毒DNA整合入宿主基因组,并重点阐述HBV X蛋白在肝细胞癌中的病理作用及其相关机制。HBV X蛋白通过促进肿瘤细胞增殖、侵袭转移,影响血管形成,促进细胞凋亡和导致代谢重组而发挥其致癌作用。深化对HBV X蛋白生物学功能、免疫失衡以及病毒DNA整合的相关研究将有助于阐明肝癌的发生机制,促进HBV相关肝癌新型治疗靶标的开发。

Hepatocellular carcinoma(HCC)is one of the major malignant tumors that lead to death,and chronic hepatitis B virus(HBV)infection is an important risk factor for HCC.This article introduces the detailed mechanisms of HBV-related HCC,including HBV X protein,immune imbalance,and integration of HBV DNA into the host genome,with a focus on the pathological role and related mechanisms of HBV X protein in HCC.HBV X protein enhances carcinogenesis by promoting tumor cell proliferation,invasion,and metastasis,affecting angiogenesis,promoting cell apoptosis,and interfering with cell metabolism.In-depth studies on the biological functions of HBV X protein,immune imbalance,and HBV DNA integration will help to clarify the pathogenesis of liver cancer and promote the development of novel therapeutic targets for HBV-related HCC.