糖尿病和非酒精性脂肪性肝病相关肝细胞癌的相互关系

Association between diabetes and nonalcoholic fatty liver disease-related hepatocellular carcinoma

肝细胞癌(HCC)是常见的恶性肿瘤之一。随着抗病毒治疗的发展和人们生活方式的改变,HCC的主要致病因素正在由病毒性肝炎逐渐转化为非酒精性脂肪性肝病。糖尿病是常见的慢性病之一,目前同时患有糖尿病和非酒精性脂肪性肝病的患者数量越来越多。糖尿病和非酒精性脂肪性肝病具有共同的相互作用机制,并且糖尿病也会促进非酒精性脂肪性肝病进展,以及增加HCC患病风险。现就糖尿病和非酒精性脂肪性肝病与HCC的相互关系进行综述。

Hepatocellular carcinoma(HCC)is one of the most common malignant tumors.With the development of antiviral therapy and the changes in lifestyle,the main pathogenic factor of HCC gradually changes from viral hepatitis to nonalcoholic fatty liver disease.Diabetes mellitus is a common chronic disease,and at present,there is an increasing number of patients with both nonalcoholic fatty liver disease and diabetes.Nonalcoholic fatty liver disease and diabetes share some common mechanisms,and diabetes may promote the progression of nonalcoholic fatty liver disease and increase the risk of HCC.This article reviews the association of diabetes and nonalcoholic fatty liver disease with HCC.