摘要
17β-羟基类固醇脱氢酶13(HSD17B13)是一种新型肝细胞特异性脂滴相关蛋白,参与肝细胞脂质合成。最近的研究发现,HSD17B13基因的插入缺失变体与慢性肝脏疾病风险降低相关。然而HSD17B13具体的生物学功能和参与肝脏疾病的发病机制尚不明确。阐述了HSD17B13的生物学功能及其在酒精性肝病中的作用机制及临床应用研究进展。
As a new hepatocyte-specific lipid droplet-related protein,17β-hydroxysteroid dehydrogenase 13(HSD17B13)is involved in hepatocyte lipid synthesis.Recent studies have shown that an insertion-deletion variant of the HSD17B13 gene is associated with a reduced risk of chronic liver diseases;however,the specific biological function of HSD17B13 and its involvement in the pathogenesis of liver diseases remain unclear.This article elaborates on the biological function of HSD17B13,its mechanism of action in alcohol-related liver,and the research advances in clinical application.
作者
李理
陈海震
黄晶
LI Li;CHEN Haizhen;HUANG Jing(Department of Clinical Laboratory,The First Hospital of Jilin University,Changchun 130021,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第10期2360-2363,共4页
Journal of Clinical Hepatology
基金
吉林省财政厅医疗卫生人才专项(JLSCZD2019-028)。
关键词
肝疾病
酒精性
17-羟甾类脱氢酶类
基因表达调控
liver diseases,alcoholic
17-hydroxysteroid dehydrogenases
gene expression regulation