17β-羟基类固醇脱氢酶13在酒精性肝病中的作用机制及临床应用

Mechanism of action and clinical application of 17β-hydroxysteroid dehydrogenase 13 in alcohol-related liver diseases

17β-羟基类固醇脱氢酶13(HSD17B13)是一种新型肝细胞特异性脂滴相关蛋白,参与肝细胞脂质合成。最近的研究发现,HSD17B13基因的插入缺失变体与慢性肝脏疾病风险降低相关。然而HSD17B13具体的生物学功能和参与肝脏疾病的发病机制尚不明确。阐述了HSD17B13的生物学功能及其在酒精性肝病中的作用机制及临床应用研究进展。

As a new hepatocyte-specific lipid droplet-related protein,17β-hydroxysteroid dehydrogenase 13(HSD17B13)is involved in hepatocyte lipid synthesis.Recent studies have shown that an insertion-deletion variant of the HSD17B13 gene is associated with a reduced risk of chronic liver diseases;however,the specific biological function of HSD17B13 and its involvement in the pathogenesis of liver diseases remain unclear.This article elaborates on the biological function of HSD17B13,its mechanism of action in alcohol-related liver,and the research advances in clinical application.