白藜芦醇在神经系统疾病中的研究进展

Research Progress of Resveratrol in Nervous System Diseases

白藜芦醇是一种天然的多酚类化合物,主要存在于葡萄、花生和虎杖等植物中,是芪属植物抗毒素的活性成分之一。白藜芦醇具有一定的神经保护作用,其机制可能包括抗氧化、抗炎、保护线粒体和(或)诱导细胞自噬等。在多种神经系统疾病中,如脑卒中、癫痫、疼痛、阿尔茨海默病和帕金森病等,白藜芦醇表现出明显的神经保护作用,但其在不同疾病中发挥作用的具体分子机制和靶点尚未明确。未来,深入研究白藜芦醇在神经系统疾病中的作用机制将为其预防和治疗提供新思路。

Resveratrol is a natural polyphenolic compound,which is mainly found in grapes,peanuts,polygonum cuspidatum and other plants.It is one of the active ingredients of antitoxin in astragalus plants.Resveratrol has some neuroprotective effects,and its mechanisms may include anti-oxidant,anti-inflammatory,mitochondrial protection and(or)induction of autophagy.In a variety of nervous system diseases,such as stroke,epilepsy,pain,Alzheimer′s disease and Parkinson′s disease,resveratrol showed significant neuroprotective effects,but the specific molecular mechanisms and targets of its role in different diseases have not been clarified.In the future,further study on the mechanism of resveratrol in nervous system diseases will provide new ideas for the prevention and treatment.