非甾体抗炎药防治乳腺癌的研究进展

Research Progress of Non-steroidal Anti-inflammatory Drugs against Breast Cancer

阿司匹林等非甾体抗炎药(NSAIDs)与乳腺癌的防治有密切联系,NSAIDs主要通过抑制体内环加氧酶活性影响前列腺素的合成从而发挥抗乳腺癌作用,但其对乳腺癌的发病率、死亡率、复发和转移的影响程度尚存在争论。长期服用阿司匹林使高乳腺癌风险患者获益的同时也增加了溃疡、出血等的发生风险,因此如何进行风险获益分析也成为一个重要问题。NSAIDs作为癌症防治的新方向,有足够的证据支持NSAIDs在乳腺癌预防和复发中的作用,但仍需要更多大规模的基础实验及临床试验进一步研究与论证。

Non-steroidal anti-inflammatory drugs(NSAIDs)are closely associated with preventing and treating breast cancer.NSAIDs play an important role in preventing breast cancer by inhibiting cyclooxygenase activity,but its effect on the morbidity and mortality,recurrence and metastasis of breast cancer remains controversial.Long-term aspirin use benefits patients with high risk of breast cancer,but it also increases the risk of ulcers and bleeding,so how to conduct risk benefit analysis has become an important issue.NSAIDs as a new direction for cancer prevention and control.There is enough evidence to support the role of NSAIDs in breast cancer prevention and recurrence,but more large-scale basic experiments and clinical studies are still needed for further research and demonstration.