输血相关急性肺损伤发病机制及防治措施研究进展

Advances in the Pathogenesis,Prevention,and Treatment of Transfusion-related Acute Lung Injury

输血相关急性肺损伤(TRALI)是输血导致的严重肺部并发症,已成为输血导致死亡的主要原因之一,其病理生理学机制尚未完全阐明,防治也面临巨大挑战。当前研究大多基于各种假说,探究多种效应细胞及效应分子在TRALI中的作用及可能存在的相关机制,本文总结了TRALI发病机制及防治措施的研究进展。

Transfusion-related acute lung injury(TRALI)is a severe pulmonary complication of transfusion and has been one of the leading causes of transfusion-associated deaths.However,the pathogenesis of TRALI is still unclear,and treatment and prevention of this condition also face huge challenges.Many recent studies have explored the roles of various effector cells and effector molecules in TRALI and possible related mechanisms based on various hypotheses,in order to find the key factors that induce TRALI and the potential prevention measures.This article reviews the pathogenesis,prevention,and treatment of TRALI.