利福平注射液-胶囊序贯治疗肺结核的临床效果及对患者肝功能的影响

Clinical effect of rifampicin injection-capsule sequential treatment of pulmonary tuberculosis and its effect on liver function of patients

目的探究利福平注射液-胶囊序贯治疗肺结核的临床效果及对患者肝功能的影响。方法选取105例肺结核患者,随机分为试验组53例、对照组52例,试验组予以利福平注射液-胶囊序贯治疗,对照组予以利福平胶囊治疗,观察治疗效果。结果试验组治疗有效率为92.45%、对照组有效率为73.08%,试验组治疗有效率更高,差异有统计学意义(P<0.05);治疗后,两组丙氨酸氨基转移酶、谷氨酰基转移酶、总胆红素水平均有所降低,但试验组较对照组更低,差异有统计学意义(P<0.05);试验组不良反应发生率为9.43%、对照组为28.85%,试验组不良反应发生率更低,差异有统计学意义(P<0.05)。结论对肺结核患者应用利福平注射液-胶囊序贯治疗,能有效减轻抗结核药物对患者肝功能损害,用药安全性较高,治疗效果显著。

Objective To explore the clinical effect of rifampicin injection-capsule sequential treatment of pulmonary tuberculosis and its effect on patients'liver function.Methods 105 patients with pulmonary tuberculosis in our hospital were randomly divided into an experimental group of 53 cases and a control group of 52 cases.The test group was treated with rifampicin injection-capsule sequential treatment,and the control group was treated with rifampicin capsules to observe the therapeutic effect.Results The effective rate of treatment in the test group was 92.45%,and the effective rate in the control group was 73.08%.Compared with the control group,the effective rate of treatment in the test group was significantly higher(P<0.05);after treatment,both two groups liver function-related indexes such as aminoacyltransferase,glutamyltransferase and total bilirubin have increased,but the test group is significantly lower than the control group(P<0.05);the incidence of adverse reactions in the test group is 9.43%,the control group is 28.85%,The incidence of adverse reactions in the test group was significantly lower(P<0.05).Conclusion The sequential treatment of rifampicin injection-capsules in patients with pulmonary tuberculosis can effectively reduce the liver function damage of patients with anti-tuberculosis drugs.The safety of the drugs is high,and the treatment effect is remarkable.