前列地尔对不同Irisin基因rs16835198的糖尿病肾病患者疗效的影响

Efficacy of alprostadil in patients with diabetic nephropathy with different types of Irisin gene rs16835198

目的分析前列地尔对不同Irisin基因rs16835198的糖尿病肾病(diabetic nephropathy,DN)患者疗效的影响。方法将惠州市第三人民医院2018年6月至2019年10月间收治的110例DN患者作为研究对象;所有患者均采用前列地尔治疗,检测患者Irisin基因rs16835198多态性,检测患者血中总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇、同型半胱氨酸(homocysteine,Hcy)、血β2微球蛋白(β2-microglobulin,β2-MG)、尿白蛋白排泄率(urinary albumin excretion rate,UAER)、空腹血糖、糖化血红蛋白、凝血酶原时间、血小板、活化部分凝血活酶时间、纤维蛋白原、血肌酐水平,并计算估算肾小球滤过率。结果不同rs16835198基因型患者性别、年龄、病程及体质量指数差异无统计学意义(P>0.05);治疗后所有患者血中TC、TG、LDL-C、Hcy、β2-MG及UAER水平均明显低于治疗前,且差异有统计学意义(P<0.05);治疗后不同rs16835198基因型患者血中TC、TG、LDL-C、Hcy、β2-MG及UAER水平有明显差异,其中TT型患者血中各指标最低,GG型最高,且差异有统计学意义(P<0.05)。结论前列地尔对于Irisin基因rs16835198为TT型的DN患者治疗疗效最佳。

Objective To analyze the efficacy of alprostadil in patients with diabetic nephropathy(DN)with different types of the Irisin gene rs16835198.Methods A total of 110 patients with DN treated in our hospital from June 2018 to October 2019 were used as the research object;and all patients were treated with alprostadil.Polymorphism of the Irisin gene rs16835198 in the patients was detected.The blood total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),β2-microglobulin(β2-MG),urinary albumin excretion rate(UAER),fasting plasma glucose,glycosylated hemoglobin,prothrombin time,platelet,activate partial thromboplastin time,fibrinogen and serum creatinine levels were tested.Estimated glomerular filtration rate was calculated.Results There was no statistically significant difference in gender,age,duration and body mass index among the patients with different rs16835198 genotypes(P>0.05).The levels of TC,TG,LDL-C,Hcy,β2-MG and UAER in the blood of patients after treatment were significantly lower than before treatment.And the difference was statistically significant(P<0.05).The levels of TC,TG,LDL-C,Hcy,β2-MG,and UAER in blood of patients with different rs16835198 genotypes were significantly different after treatment,among which the blood indicators in the patients with the genotype TT were the lowest,and those in the patients with the genotype GG was the highest,with statistically significant difference(P<0.05).Conclusions Alprostadil has the best efficacy in the DN patient whose Irisin gene rs16835198 is TT type.