尼可地尔对STEMI患者PCI术后的作用效果

The Effect of Nicorandil on STEMI Patients After PCI

目的本文旨在研究对ST段抬高型心肌梗死(ST segment elevation myocardial infarction,STEMI)患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术中发生无复流情况后运用尼可地尔相对常规硝酸甘油注射的效果比较。方法回顾性选取2019年1—12月于我院心血管内科住院治疗的冠心病需行PCI术的患者共计84例。根据PCI术中无复流现象处理方式不同分为观察组41例及对照组43例。观察组无复流后注射尼可地尔,对照组注射硝酸甘油。分别对两组患者的用药后无复流发生率、治疗后ST段回落率及3周后左室射血分数进行比较。结果用药后观察组患者的无复流发生率17.07%(7/41)低于对照组41.86%(18/43);观察组患者ST段回落率90.24%(37/41)高于对照组67.44%(29/43);观察组1周后左室射血分数(75.321±11.782)%高于对照组(62.371±9.383)%,差异具有统计学意义(P <0.05)。结论 STEMI患者PCI术中发生无复流情况后运用尼可地尔相对常规硝酸甘油注射的效果更好,更有利于患者恢复。

Objective To study the using of nicorandil for patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI)without reflow.Comparison of the effects of conventional nitroglycerin injections.Methods Selected 84 patients with coronary heart disease requiring PCI in the Department of Cardiology of our hospital from January to December 2019.According to the treatment of no-reflow phenomenon during PCI,41 cases were divided into observation group and 43 cases in control group.The observation group was injected with nicorandil after no reflow,and the control group was injected with nitroglycerin.Compared the incidence of no-reflow after medication,the rate of ST segment fall after treatment,and the left ventricular ejection fraction after 3 weeks.Results After medication,the incidence of no-reflow in the observation group was 17.07%(7/41)lower than 41.86%(18/43)in the control group;the ST segment fall rate of the observation group was 90.24%(37/41)higher than the control group 67.44%(29/43);The left ventricular ejection fraction(75.321±11.782)%of the observation group was higher than that of the control group(62.371±9.383)%after 1 week,and the difference was statistically significant(P<0.05).Conclusion Nicorandil is more effective than conventional nitroglycerin injection after no reflow occurs during PCI in STEMI patients,and is more conducive to the recovery of patients.