不明复发性流产者血清HMGB1、IL-33与免疫指标关系

The correlation between the levels of serum HMGB1 and IL-33 in women with unexplained recurrent spontaneous abortion and their immune indexes

目的:探究不明复发性流产者(URSA)血清高迁移率族蛋白B1(HMGB1)、白细胞介素-33(IL-33)、IL-6、IL-10、IL-17、转化生长因子-β(TGF-β)的关系。方法:收集本院就诊的早孕妇女126例,对比URSA孕妇(URSA组66例)与正常早孕孕妇(正常组60例)血清HMGB1、IL-33与IL-6、IL-10、IL-17、TGF-β的变化及其相关性。结果:URSA组血清HMGB1、IL-6、IL-17水平均高于正常组,血清IL-33、IL-10、TGF-β水平均低于正常组(P<0.05)。URSA组血清HMGB1与IL-6、IL-17水平呈正相关,与IL-10、TGF-β水平呈负相关;血清IL-33与IL-6、IL-17水平呈负相关,与IL-10、TGF-β呈正相关(均P<0.05)。结论:URSA早孕孕妇血清HMGB1水平上调,IL-33水平下调,可能通过调节Thl7、Treg细胞因子水平参与了疾病的发生。

Objective: To investigate the correlation between the levels of serum HMGB1, IL-33, IL-6, IL-10, IL-17 and TGF-βof women with unexplained recurrent spontaneous abortion(URSA) and their immune indexes. Methods: 126 pregnant women were selected and were divided in study group(66 women with URSA) and in control group(60 normal women). The changes of serum HMGB1, IL-33, IL-6, IL-10, IL-17, and TGF-βlevels of women were compared between the two groups. And their correlation was analyzed. Results: The levels of the serum HMGB, IL-6 and IL-17 of women in the study group were significant higher than those of women in the control group, but the levels of serum IL-33, IL-10 and TGF-βof women in the study group were significant lower(P<0.05). In the study group, serum HMGB1 level was positively correlated with IL-6 and IL-17 levels, but was negatively correlated with IL-10 and TGF-β levels(P<0.05). In the study group, serum IL-33 level was negatively correlated with IL-6 and IL-17 levels, but was positively correlated with IL-10 and TGF-βlevels(P<0.05). Conclusion: HMGB1 expression of women with URSA during the first trimester of pregnancy is up regulation, but the level of IL-33 is down regulation, which may be involved in the occurrence of the disease by regulating the level of cytokines of Thl7 and Treg cell.