低分子肝素治疗肾病综合征的疗效分析

Effect of Low Molecular Weight Heparin in the Treatment of Nephrotic Syndrome

目的:探讨肾病综合征(NS)患儿应用低分子肝素治疗的效果。方法:选取我院2018年3月—2019年2月收治的192例NS患儿作为观察对象,将其随机分为各有96例患儿的两组:治疗组和对照组。对照组患儿应用泼尼松治疗,治疗组患儿应用泼尼松与低分子肝素治疗。所有患儿均治疗4周,对临床治疗效果、肾功能指标、凝血功能指标进行比较。结果:治疗组患儿在临床治疗总有效率方面显著高于对照组,差异有显著性(P<0.05)。两组治疗前24h尿蛋白、BUN、Scr、UAER水平之间不具有显著性差异(P>0.05)。两组患儿经过治疗,上述肾功能指标均明显低于治疗前,且治疗组较对照组明显降低(P<0.05)。两组治疗前PT、APTT、FIB水平之间不具有显著性差异(P>0.05)。两组患儿经过治疗,PT、APTT均高于治疗前,FIB均明显低于治疗前(P<0.05);治疗后,治疗组患儿PT、APTT水平高于对照组,FIB水平低于对照组(P<0.05)。结论:NS患儿应用低分子肝素治疗的效果满意,患儿肾功能及凝血功能均明显改善,临床推广与应用的价值较高。

Objective:To investigate the effect of low molecular weight heparin in the treatment of nephrotic syndrome(NS).Methods:192 cases of NS children in our hospital from March 2018 to February 2019 were selected as the observation objects,and they were randomly divided into two groups with 96 children in each group:the treatment group and the control group.The control group was treated with prednisone,while the treatment group was treated with prednisone and low molecular weight heparin.All the patients were treated for 4 weeks.The clinical therapeutic effect,renal function index and coagulation function index were compared.Result:The total effective rate of the treatment group was significantly higher than that of the control group,the difference was significant(P<0.05).There was no significant difference in 24 h urine protein,bun,SCR and UAER levels between the two groups before treatment(P>0.05).After treatment,the above renal function indexes of the two groups were significantly lower than before treatment,and the treatment group was significantly lower than the control group(P<0.05).There was no significant difference in Pt,APTT and FIB levels between the two groups before treatment(P>0.05).After treatment,Pt and APTT of the two groups were higher than those before treatment,and FIB were significantly lower than those before treatment(P<0.05);after treatment,Pt and APTT levels in the treatment group were higher than those in the control group,and FIB levels were lower than those in the control group(P<0.05).Conclusion:The effect of low molecular weight heparin in the treatment of NS children is satisfactory,the renal function and coagulation function of children are significantly improved,and the value of clinical promotion and application is high.