叶酸、甲钴胺、尼莫地平治疗脑小血管病所致认知功能障碍的疗效

Effect of Folic Acid,Mecobalamin and Nimodipine in the Treatment of Cognitive Dysfunction Caused by Cerebral Small Vessel Disease

目的:研究叶酸、甲钴胺与尼莫地平合用对脑小血管病所致认知功能障碍的治疗效果。方法:2017年4月—2019年4月期间,选择我院116例脑小血管病所致认知功能障碍患者为研究对象,随机分为实验组和参照组,各58例;实验组采取叶酸、甲钴胺与尼莫地平合用治疗,参照组采取尼莫地平治疗,比较两组患者的治疗有效率、认知功能情况以及不良反应。结果:经治疗,实验组患者的治疗有效率明显高于参照组,P<0.05;实验组患者的认知功能改善效果优于参照组,P<0.05;两组患者不良反应发生情况无可比性,P>0.05。结论:叶酸、甲钴胺与尼莫地平合用对脑小血管病所致认知功能障碍治疗效果良好,另外对认知功能有较大改善,且不良反应发生较少,有应用价值。

Objective:To study the effect of folic acid,mecobalamin and nimodipine on cognitive dysfunction caused by cerebral small vessel disease.Method:From April 2017 to April 2019,116 patients with cognitive impairment caused by cerebral small vessel disease were selected and randomly divided into experimental group and reference group,with 58 cases in each group;the experimental group was treated with folic acid,mecobalamin and nimodipine,while the reference group was treated with nimodipine.The treatment efficiency,cognitive function and adverse reactions of the two groups were compared.Result:After treatment,the effective rate of the experimental group was significantly higher than that of the reference group,P<0.05;the cognitive function improvement effect of the experimental group was better than that of the reference group(P<0.05);the incidence of adverse reactions in the two groups was not comparable(P>0.05).Conclusion:Folic acid,Mecobalamin Combined with nimodipine has good therapeutic effect on cognitive dysfunction caused by cerebral small vessel disease.In addition,it has great improvement on cognitive function and has less adverse reactions,so it has application value.