高剂量和低剂量肺表面活性物质治疗新生儿呼吸窘迫综合征的疗效对比

High-Dose and Low-Dose Pulmonary Surfactants in the Treatment of Neonatal Respiratory Distress Syndrome

目的:对比高剂量的肺表面活性物质(PS)与低剂量PS治疗新生儿ARDS疗效;方法:取44例PS以150~200mg/kg(1.5~3mL/kg)剂量治疗为高剂量组,取40例PS以50~100mg/kg(0.75~1.5mL/kg)治疗为低剂量组;结果:高剂量组临床总有效率90.91%高于低剂量组75%,高剂量组患儿PaO2、PaO2/FiO2、pH值高于低剂量组,而PaCO2水平低于低剂量,且P<0.05;结论:PS治疗新生儿ARDS疗效显著,改善患儿血气指标明显。

Objective:To compare the efficacy of high-dose pulmonary surfactant(PS)and low-dose PS in the treatment of neonatal ARDS.Method:44 cases of PS were treated with 150~200mg/kg(1.5~3mL/kg)as the high-dose group,and 40 cases of PS were taken 50~100mg/kg(0.75~1.5mL/kg)was treated as a low-dose group.Results:The total clinical effective rate in the high-dose group was 90.91%higher than 75%in the low-dose group,and the PaO2,PaO2/FiO2,and PH values in the high-dose group were higher In the low-dose group,the PaCO2 level was lower than that in the low-dose group,and P<0.05.Conclusion:PS is effective in the treatment of neonatal ARDS and improves the blood gas index of children.