桑叶代茶饮联合二甲双胍对肺热津伤证2型糖尿病患者的临床疗效

Clinical effects of Mori Folium drink as tea combined with metformin on patients with type 2 diabetes mellitus due to Lung Heat and Fluid-Humor Injury

目的考察桑叶代茶饮联合二甲双胍对肺热津伤证2型糖尿病患者的临床疗效。方法80例患者随机分为对照组和观察组,每组40例,另选择40例血糖调节正常的健康人群作为正常组,对照组给予二甲双胍,观察组在对照组基础上加用桑叶代茶饮,疗程3个月。检测血糖指标(FBG、2 hPBG、HbA1c)、FINS、HOMA-IR、炎症因子(IL6、TNF-α)、中医证候评分变化。结果治疗后,对照组、观察组血糖指标降低(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组FINS、HOMA-IR、中医证候总评分及口渴喜饮、口干咽燥、烦热评分降低(P<0.05),也低于对照组(P<0.05);2组炎症因子降低(P<0.05),观察组IL-6低于对照组(P<0.05)。结论桑叶代茶饮联合二甲双胍可有效改善肺热津伤证2型糖尿病患者中医证候评分及胰岛素抵抗,抑制IL-6水平。

AIM To investigate the clinical effects of Mori Folium drink as tea combined with metformin on patients with type 2 diabetes mellitus due to Lung Heat and Fluid-Humor Injury.METHODS Eighty patients were randomly assigned into control group(40 cases)for 3-month administration of metformin,and observation group(40 cases)for 3-month administration of both Mori Folium drink as tea and metformin,and another 40 healthy people with normal blood glucose control were recruited into normal group.The changes in blood glucose indices(FBG,2 hPBG,HbA1c),FINS,HOMA-IR,inflammatory factors(IL-6,TNF-α)and TCM symptom scores were detected.RESULTS After the treatment,the control group and the observation group demonstrated decreased blood glucose indices(P<0.05),but the difference was not statistically significant between group comparison(P>0.05).The observation group displayed decreased FINS,HOMA-IR,total score for TCM symptoms,and scores for thirst with liking for fluids,dry mouth and throat,dysphoria with smothery sensation(P<0.05),which were also lower than those in the control group(P<0.05).The two groups exhibited decreased inflammatory factors(P<0.05),and the observation group showed lower IL-6 than the control group(P<0.05).CONCLUSION For the patients with type 2 diabetes mellitus due to Lung Heat and Fluid-Humor Injury,Mori Folium drink as tea combined with metformin can effectively improve TCM symptom scores and insulin resistance,and inhibit IL-6 level.