基于数据挖掘及复杂网络技术探讨周仲瑛教授治疗哮喘发作期经验

Discussing Professor Zhou Zhongying′s Experience in Asthma Attack Based on Data Mining and Complex Network Technology

目的通过病案数据挖掘及复杂网络技术探讨周仲瑛辨治哮喘发作期的“机-证-药-方”经验。方法收集整理周仲瑛教授门诊经治的哮喘发作期病例记录,纳入189例,共612诊次病例,对病例信息化处理后,通过频数分析、因子分析、关联规则方法,运用复杂网络分析建立网络模型,对病机、处方、用药、核心处方等多方面进行数据分析。结果病机频次最高的是风痰伏肺,病位主要在肺,亦涉及心肝脾胃肾大肠等脏腑,病理因素以风、痰为主,亦有寒、热、湿、饮、瘀、气滞等。周仲瑛教授辨治哮喘发作期的核心药物为炙麻黄、苏子、法半夏、炙甘草、陈皮、白前、射干、桑白皮、僵蚕、苍耳草、露蜂房、杏仁、黄芩、北沙参、南沙参、太子参。结论周仲瑛教授哮喘发作期的辨治规律:祛风化痰为治疗大法;虚实相因,祛邪不忘扶正;把握病机证素间的兼夹转化,复法合治;小方复合,灵活运用;辨明寒热,分而治之。

Objective:To explore Zhou Zhongying′s experience of identifying“machine-certificate-medicineprescription”in the treatment of asthma attacks through the medical records data mining and complex network technology.Methods:The records of asthma attack cases treated by Professor Zhou Zhongying in the outpatient clinic were collected and sorted out,including 189 cases with a total of 612 consultations.After the information processing of the cases,the frequency analysis,factor analysis,and association rule methods were used to establish a network model using complex network analysis to analyze the data of pathogenesis,prescription,medication,core prescription and other aspects.Results:The most frequent pathogenesis was wind-phlegm syndrome,and the disease was mainly in the lungs;it also involved the heart,liver,spleen,stomach,kidney,and large intestine.The pathological factors were mainly wind and phlegm.There were also cold,heat,dampness,drinking,stasis,and qi stagnation.Professor Zhou Zhongying′s core drugs for the treatment of asthma attacks were Roasted ephedra,perillaseed,French pinellia,Roasted licorice,tangerine peel,Cynanchum glaucescens,Belamcanda sinensis,Cortex Mori,Bombyx batryticatus,Xanthium sibiricum,Nidus vespae,Almond,Scutellaria baicalensis,Radix glehniae,Radix Adenophorae,and Radix Pseudostellariae.Conclusion:Professor Zhou Zhongying′s laws of differentiation and treatment during asthma attack:expelling wind and phlegm is the main method of treatment;truth and facts are related,and evil is not forgotten and righting;grasp the transformation of pathogenesis,syndromes,and syndromes;combine the small prescription and use them flexibly;identify cold and heat,divide them for treatment.