耗散型石英晶体微天平在生物医用高分子材料中的应用

Application of Quartz Crystal Microbalance with Dissipation in Biomedical Polymer Materials

石英晶体微天平(QCM)是一种基于石英晶体压电效应的分析检测技术,可实时在线提供石英晶体表面吸附层质量、厚度、粘弹性等信息,由此获得表面分子相互作用关系。耗散型石英晶体微天平(QCM-D)因其独特的对粘弹性的解析,使其在高分子材料中的应用迅速发展,尤其是生物医用高分子材料领域,已用来评价生物医用高分子材料的表界面相互作用,力学和生物相容性等。本文简单介绍了耗散型石英晶体微天平的基本原理及理论模型,重点综述了近几年QCM-D在高分子链构象、蛋白质吸附、生物大分子相互作用、药物释放以及水凝胶中的应用,并且展望了QCM-D的未来发展趋势。

Quartz crystal microbalance(QCM)is an analytical technique based on the piezoelectric effect of quartz crystal,which can provide the information on the mass,thickness and viscoelasticity of the adsorbed layer on the surface of quartz crystal in real time,and thus obtain the surface molecular interaction relationship.Because of the unique viscoelastic analysis,QCM with dissipation(QCM-D)has been rapidly applied in the field of polymer material,especially for biomedical polymer materials.It has been used to evaluate the surface and interface interaction,mechanical property,and biocompatibility of biomedical biomaterials.In this review,the basic principle and theoretical model of QCM-D are briefly introduced.The application of QCM-D in the conformation of polymer chain,protein adsorption,biomolecular interactions,drug release and hydrogels in recent years are emphatically reviewed,and finally the future development trends of QCM-D is forecasted.